GENERAL PATHOLOGY for veterinary students

Spis treci

Paramount definitions ... 9
CHAPTER 1.
PATHOLOGY – THE SCIENCE OF DISEASE ... 13
Rafa Sapierzyski
Introduction. General problems: a definition of pathology, division of disciplines in pathology ... 13
Pathologist’s workshop ... 16
Pathologist’s tasks ... 29
References ... 30
CHAPTER 2.
AN OUTLINE OF THE HISTORY OF PATHOMORPHOLOGY ... 31
Magorzata Sobczak-Filipiak
Joint history of medicine and veterinary medicine ... 31
Pathological anatomy as a separate field of science ... 33
Early days of pathomorphology in Poland ... 33
Veterinary medicine – vocational education ... 34
Pathological anatomy in study curricula ... 35
Our collaborators ... 36
References ... 39
CHAPTER 3.
ETIOLOGICAL FACTORS ... 41
Anna Rodo
Introduction ... 41
Genetic factors ... 41
Physical factors ... 42
Biological factors ... 50
Chemical factors ... 60
Nutritional factors ... 70
References ... 73
CHAPTER 4.
EVERYTHING ORIGINATES FROM THE CELL ... 75
Katarzyna Kliczkowska Klarowicz
Introduction ... 75
Animal cell structure ... 75
Osmotic balance in the cell ... 77
Mechanisms of cellular damage ... 78
References ... 81
CHAPTER 5.
LETHAL DAMAGE, CELL DEATH AND DEATH OF THE ORGANISM ... 83
Magorzata Sobczak-Filipiak
Introduction ... 83
Necrosis ... 83
Apoptosis ... 94
Death of the organism ... 97
References ... 106
CHAPTER 6.
SUBLETHAL INJURY – PROGRESSIVE DAMAGE – DEGENERATION ... 107
Izabela Dolka
Introduction ... 107
Mechanisms of intracellular accumulation ... 109
Water and electrolyte metabolism disorders ... 110
Protein metabolism disorder including amyloid degeneration ... 113
Lipid metabolism disorders ... 137
Carbohydrate metabolism disorders ... 147
Pigment metabolism disorders ... 150
Copper metabolism disorders ... 173
Mineral metabolism disorders ... 175
References ... 194
CHAPTER 7.
CIRCULATORY SYSTEM DISORDERS ... 197
Hanna Sendecka
Introduction ... 197
Abnormal filling of blood vessels ... 197
Blood cell concentration and structure disorders ... 205
Haemorrhages ... 208
Coagulation disorders ... 215
Embolism and infarction as its consequence ... 223
Non-inflammatory oedema ... 228
Shock ... 236
Blood vessel structure disorders ... 241
References ... 244
CHAPTER 8.
TERATOLOGY – CONGENITAL DISORDERS ... 245
Rafa Sapierzyski
Introduction ... 245
Pathogenesis of congenital disorders ... 248
Causes of congenital disorders ... 249
The classification of malformations – structural teratogenesis ... 259
References ... 268
CHAPTER 9.
DISORDERS OF CELLULAR GROWTH, MATURATION AND DIFFERENTIATION ... 269
Rafa Sapierzyski
Introduction ... 269
Capacity of cells and tissues for proliferation and differentiation ... 272
Adaptation ... 275
Disorders of growth, maturation and differentiation of cells ... 276
References ... 302
CHAPTER 10.
ACUTE INFLAMMATION ... 303
Wojciech Bielecki
Introduction ... 303
Inflammatory reaction components ... 308
The course of acute inflammatory reaction ... 313
The morphological picture of acute inflammation ... 316
Outcome of acute inflammation ... 325
Systemic effects of acute inflammation ... 327
References ... 328
CHAPTER 11.
CHRONIC INFLAMMATION AND TISSUE REPAIR ... 329
Wojciech Bielecki
Introduction ... 329
The role of inflammatory infiltration cells ... 330
The mechanism of development and causes of chronic inflammation ... 333
Granulomatous inflammation ... 335
Tissue repair ... 342
References ... 350
CHAPTER 12.
BASICS OF IMMUNOPATHOLOGY ... 351
Katarzyna Kliczkowska Klarowicz
Introduction ... 351
Immunological response ... 351
Immune system cells ... 352
Immune system disorders ... 354
References ... 372
CHAPTER 13.
NEOPLASIA ... 373
Rafa Sapierzyski
Introduction ... 373
General characteristics of neoplasms ... 373
Etiopathogenesis of neoplasms ... 399
Biological behaviour of malignant neoplasms ... 422
Tumour – host relationships ... 443
Clinical aspects of neoplastic disease in animals – the outline of clinical oncology ... 459
References ... 470